Since 2012 we have been conducting international research on the Meibomian Gland Atrophy and Contact Lens Dropout. We have been, and still are represented at many international congresses, such as American Academy of Optometry or Association of Research in Vision and Ophthalmology. Our comprehensive research is written down in many Abstracts and Posters. Currently, three international peer reviewed publications are available. We look forward for even more comprehensive resarch about MGD, Contact Lenses and Dry Eye.
2019
Lisa A. Jones-Jordan Andrew D. Pucker, Carolina M. E. Kunnen
Impact of meibomian gland width on successful contact lens use Journal Article
In: Contact Lens and Anterior Eye, 42 (6), pp. 646-651, 2019.
@article{Pucker2019b,
title = {Impact of meibomian gland width on successful contact lens use},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Carolina M.E. Kunnen, Sebastian Marx, Daniel R. Powell, Justin T. Kwan, Sruthi Srinivasan, Wolfgang Sickenberger, Lyndon Jones},
url = {https://classstudygroup.com/wp-content/uploads/2019/11/Impact-of-meibomian-gland-width-on-successful-contact-lens-use.pdf
https://www.sciencedirect.com/science/article/pii/S1367048419300220?dgcid=coauthor},
doi = {https://doi.org/10.1016/j.clae.2019.06.004},
year = {2019},
date = {2019-12-01},
journal = {Contact Lens and Anterior Eye},
volume = {42},
number = {6},
pages = {646-651},
abstract = {Purpose: To evaluate meibomian gland (MG) width and determine its impact on successful contact lens (CL) use and ocular health. Methods: A five-site study was conducted by recruiting 18- to 45-year-old subjects who had dropped out of CLs because of discomfort. CL dropouts were compared to age- and sex-matched successful CL wearers. Right eyes were evaluated for tear break-up time, tear meniscus height, MG expressibility, meibum quality, and meibography. Central MG widths were evaluated with a custom MATLAB program. Results: CL dropouts (n=56) and successful CL (n=56) wearers had similar grades for upper (p=1.0) and lower (p=0.22) MG atrophy, upper (p=0.07) and lower (p=0.89) MG tortuosity, and upper (p=0.92) and lower (p=0.97) MG widths. Upper eyelid MG widths were narrower than lower eyelid MG widths (p=0.03). Upper and lower MG tortuosity (p < 0.001) and widths (p=0.03) were associated, but not atrophy (p=0.42). Lower eyelid MG widths were associated with MG expressibility (p=0.01), but MG widths were not with any other factors. Conclusions: Successful CL wear does not appear to be clinically influenced by MG width or other measures of MG structural integrity. Lower eyelid MGs were wider than upper eyelid MGs and narrower lower eyelid MGs were associated with worse MG expressibility, suggesting that narrower MGs may produce abnormal meibum. Data also suggests that MG factors of both eyelids should be evaluated in practice.
},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Purpose: To evaluate meibomian gland (MG) width and determine its impact on successful contact lens (CL) use and ocular health. Methods: A five-site study was conducted by recruiting 18- to 45-year-old subjects who had dropped out of CLs because of discomfort. CL dropouts were compared to age- and sex-matched successful CL wearers. Right eyes were evaluated for tear break-up time, tear meniscus height, MG expressibility, meibum quality, and meibography. Central MG widths were evaluated with a custom MATLAB program. Results: CL dropouts (n=56) and successful CL (n=56) wearers had similar grades for upper (p=1.0) and lower (p=0.22) MG atrophy, upper (p=0.07) and lower (p=0.89) MG tortuosity, and upper (p=0.92) and lower (p=0.97) MG widths. Upper eyelid MG widths were narrower than lower eyelid MG widths (p=0.03). Upper and lower MG tortuosity (p < 0.001) and widths (p=0.03) were associated, but not atrophy (p=0.42). Lower eyelid MG widths were associated with MG expressibility (p=0.01), but MG widths were not with any other factors. Conclusions: Successful CL wear does not appear to be clinically influenced by MG width or other measures of MG structural integrity. Lower eyelid MGs were wider than upper eyelid MGs and narrower lower eyelid MGs were associated with worse MG expressibility, suggesting that narrower MGs may produce abnormal meibum. Data also suggests that MG factors of both eyelids should be evaluated in practice.
Lisa A. Jones-Jordan Andrew D. Pucker, Carolina M. Kunnen
Impact of Meibomian Gland Width on Successful Contact Lens Use Conference
2019.
@conference{Pucker2019,
title = {Impact of Meibomian Gland Width on Successful Contact Lens Use},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Carolina M. Kunnen, Sebastian Marx, Daniel R. Powell, Justin Kwan, Shruthi Srinivasan, Wolfgang Sickenberger, Lyndon Jones},
year = {2019},
date = {2019-01-24},
abstract = { },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2018
Lisa A. Jones-Jordan Daniel R. Powell, Shruthi Srinivasan
Impact of Soft Contact Lens Factors and Compliance on Contact Lens Dropout Conference
2018.
@conference{Powell2018,
title = {Impact of Soft Contact Lens Factors and Compliance on Contact Lens Dropout},
author = {Daniel R. Powell, Lisa A. Jones-Jordan, Shruthi Srinivasan, Justin Kwan, Sebastian Marx, Wolfgang Sickenberger, Lyndon Jones, Andrew D. Pucker},
year = {2018},
date = {2018-11-07},
abstract = { },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Justin Kwan Sebastian Marx, Lisa A. Jones-Jordan
Degree of Meibomian Gland Tortuosity in Successful Soft Contact Lens Wearers and Dropouts Conference
2018.
@conference{Marx2018,
title = {Degree of Meibomian Gland Tortuosity in Successful Soft Contact Lens Wearers and Dropouts},
author = {Sebastian Marx, Justin Kwan, Lisa A. Jones-Jordan, Daniel Powell, Shruthi Srinivasan, Wolfgang Sickenberger, Lyndon Jones, Andrew D. Pucker},
year = {2018},
date = {2018-11-07},
abstract = { },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Lisa A. Jones-Jordan Andrew D. Pucker, Shruthi Srinivasan
Association Between Meibomian Gland Health and Soft Contact Lens Dropout Conference
2018.
@conference{Pucker2018,
title = {Association Between Meibomian Gland Health and Soft Contact Lens Dropout},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Shruthi Srinivasan, Daniel R. Powell, Justin Kwan, Sebastian Marx, Wolfgang Sickenberger, Lyndon Jones},
year = {2018},
date = {2018-11-07},
abstract = { },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Andrew D. Pucker; Bradley E. Dougherty; Lisa A. Jones-Jordan; Justin T. Kwan; Carolina M. Kunnen, Sruthi Srinivasan
Psychometric Analysis of the SPEED Questionnaire and CLDEQ-8 Journal Article
In: 2018.
@article{Pucker2018b,
title = {Psychometric Analysis of the SPEED Questionnaire and CLDEQ-8},
author = {Andrew D. Pucker; Bradley E. Dougherty; Lisa A. Jones-Jordan; Justin T. Kwan; Carolina M. Kunnen, Sruthi Srinivasan},
doi = {10.1167/iovs.18-24016},
year = {2018},
date = {2018-07-02},
abstract = {Purpose: This study reports on the ability of the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire to detect dry eye (DE) symptoms in contact lens (CL) and non-CL wearers.
Methods: The SPEED questionnaire was administered to all subjects while the Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) was only administered to CL wearers. Tear meniscus heights (TMH) were measured, and the phenol red thread (PRT) test was conducted. These tests along with self-reported DE were used to identify subjects with dry eye disease (DED). Rasch analysis was performed to evaluate the questionnaires for measurement precision and unidimensionality, and the scores from these Rasch analyses were used to understand their ability to predict measures of DED.
Results: We enrolled 284 subjects (150 CL and 134 non-CL wearers). Mean subject age was 39.4 ± 14.2 years. Rasch analysis yielded a multidimensional short form of the SPEED questionnaire (8-items) and a unidimensional short form of the CLDEQ-8 (4-item). Scores from both questionnaires were significantly associated with self-reported DE in CL and non-CL wearers. Scores of the 8-item SPEED questionnaire were associated with DED status in non-CL wearers but not in CL wearers while 4-item CLDEQ scores were associated with DED status in CL wearers. TMH or PRT were not associated with either questionnaire in CL or non-CL wearers.
Conclusions: The 8-item SPEED questionnaire demonstrated adequate measurement precision with evidence of quantifying multiple symptoms categories while the 4-item CLDEQ-8 primarily quantified DE symptoms. Questionnaire scores were associated with self-reported DE, which suggests that they may have utility in both populations analyzed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Purpose: This study reports on the ability of the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire to detect dry eye (DE) symptoms in contact lens (CL) and non-CL wearers.
Methods: The SPEED questionnaire was administered to all subjects while the Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) was only administered to CL wearers. Tear meniscus heights (TMH) were measured, and the phenol red thread (PRT) test was conducted. These tests along with self-reported DE were used to identify subjects with dry eye disease (DED). Rasch analysis was performed to evaluate the questionnaires for measurement precision and unidimensionality, and the scores from these Rasch analyses were used to understand their ability to predict measures of DED.
Results: We enrolled 284 subjects (150 CL and 134 non-CL wearers). Mean subject age was 39.4 ± 14.2 years. Rasch analysis yielded a multidimensional short form of the SPEED questionnaire (8-items) and a unidimensional short form of the CLDEQ-8 (4-item). Scores from both questionnaires were significantly associated with self-reported DE in CL and non-CL wearers. Scores of the 8-item SPEED questionnaire were associated with DED status in non-CL wearers but not in CL wearers while 4-item CLDEQ scores were associated with DED status in CL wearers. TMH or PRT were not associated with either questionnaire in CL or non-CL wearers.
Conclusions: The 8-item SPEED questionnaire demonstrated adequate measurement precision with evidence of quantifying multiple symptoms categories while the 4-item CLDEQ-8 primarily quantified DE symptoms. Questionnaire scores were associated with self-reported DE, which suggests that they may have utility in both populations analyzed.
Methods: The SPEED questionnaire was administered to all subjects while the Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) was only administered to CL wearers. Tear meniscus heights (TMH) were measured, and the phenol red thread (PRT) test was conducted. These tests along with self-reported DE were used to identify subjects with dry eye disease (DED). Rasch analysis was performed to evaluate the questionnaires for measurement precision and unidimensionality, and the scores from these Rasch analyses were used to understand their ability to predict measures of DED.
Results: We enrolled 284 subjects (150 CL and 134 non-CL wearers). Mean subject age was 39.4 ± 14.2 years. Rasch analysis yielded a multidimensional short form of the SPEED questionnaire (8-items) and a unidimensional short form of the CLDEQ-8 (4-item). Scores from both questionnaires were significantly associated with self-reported DE in CL and non-CL wearers. Scores of the 8-item SPEED questionnaire were associated with DED status in non-CL wearers but not in CL wearers while 4-item CLDEQ scores were associated with DED status in CL wearers. TMH or PRT were not associated with either questionnaire in CL or non-CL wearers.
Conclusions: The 8-item SPEED questionnaire demonstrated adequate measurement precision with evidence of quantifying multiple symptoms categories while the 4-item CLDEQ-8 primarily quantified DE symptoms. Questionnaire scores were associated with self-reported DE, which suggests that they may have utility in both populations analyzed.
2016
Andrew D. Pucker Lisa A. Jones Jordan, Bradley Dougherty
Psychometric Analysis of the SPEED Questionnaire Conference
2016, ISBN: E-abstract 160019.
@conference{Jordan2016,
title = {Psychometric Analysis of the SPEED Questionnaire},
author = {Lisa A. Jones Jordan, Andrew D. Pucker, Bradley Dougherty, Justin Kwan, Carolina Kunnen, Sruthi Srinivasan},
url = {https://www.aaopt.org/detail/knowledge-base-article/psychometric-analysis-speed-questionnaire},
isbn = {E-abstract 160019},
year = {2016},
date = {2016-11-09},
abstract = {Purpose: The Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire was developed to evaluate the symptoms of dry eye in patients with the purpose to include an assessment of longer standing problems over the past three months. The original sample tested 50 subjects and only a few studies have further evaluated the questionnaire. This study reports on the performance of this questionnaire in a diverse sample of professional adults, and it is compared to the CLDEQ-8 for the subset of contact lens wearers.
Methods: A cross-sectional study was completed at Academy 2015 New Orleans with the SPEED questionnaire administered to the subjects along with other questions about demographics. Contact lens wearers completed the CLDEQ-8. Rasch analysis was done to evaluate the questionnaires for unidimensionality and to evaluate the performance of the individual questions. Additionally, the SPEED was correlated with the CLDEQ-8 for contact lens wearers to determine if they performed similarly.
Results: There were 284 subjects, of which 150 reported as contact lens wearers. The average age was 39.4 years ± 14.2 and 61% were female. Rasch analysis was performed initially using all of the questions on the SPEED, but the questions measuring long-term symptoms were found incompatible with the unidimensionality assumption of the model. The 8 core questions about symptom frequency and intensity were found to measure one latent variable, measurement precision was acceptable, and the model fit was reasonable. The response category structure functioned well. The CLDEQ-8 also functioned as one latent variable with acceptable measurement properties. The two scales were highly correlated in contact lens wearers (r = 0.73, p<0.001).
Conclusions: Overall, a short form of the SPEED questionnaire had good measurement properties in this large, diverse sample of adults. Both the SPEED and the CLDEQ-8 questionnaires seem to be tapping into a similar construct for dry eye symptoms.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Purpose: The Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire was developed to evaluate the symptoms of dry eye in patients with the purpose to include an assessment of longer standing problems over the past three months. The original sample tested 50 subjects and only a few studies have further evaluated the questionnaire. This study reports on the performance of this questionnaire in a diverse sample of professional adults, and it is compared to the CLDEQ-8 for the subset of contact lens wearers.
Methods: A cross-sectional study was completed at Academy 2015 New Orleans with the SPEED questionnaire administered to the subjects along with other questions about demographics. Contact lens wearers completed the CLDEQ-8. Rasch analysis was done to evaluate the questionnaires for unidimensionality and to evaluate the performance of the individual questions. Additionally, the SPEED was correlated with the CLDEQ-8 for contact lens wearers to determine if they performed similarly.
Results: There were 284 subjects, of which 150 reported as contact lens wearers. The average age was 39.4 years ± 14.2 and 61% were female. Rasch analysis was performed initially using all of the questions on the SPEED, but the questions measuring long-term symptoms were found incompatible with the unidimensionality assumption of the model. The 8 core questions about symptom frequency and intensity were found to measure one latent variable, measurement precision was acceptable, and the model fit was reasonable. The response category structure functioned well. The CLDEQ-8 also functioned as one latent variable with acceptable measurement properties. The two scales were highly correlated in contact lens wearers (r = 0.73, p<0.001).
Conclusions: Overall, a short form of the SPEED questionnaire had good measurement properties in this large, diverse sample of adults. Both the SPEED and the CLDEQ-8 questionnaires seem to be tapping into a similar construct for dry eye symptoms.
Methods: A cross-sectional study was completed at Academy 2015 New Orleans with the SPEED questionnaire administered to the subjects along with other questions about demographics. Contact lens wearers completed the CLDEQ-8. Rasch analysis was done to evaluate the questionnaires for unidimensionality and to evaluate the performance of the individual questions. Additionally, the SPEED was correlated with the CLDEQ-8 for contact lens wearers to determine if they performed similarly.
Results: There were 284 subjects, of which 150 reported as contact lens wearers. The average age was 39.4 years ± 14.2 and 61% were female. Rasch analysis was performed initially using all of the questions on the SPEED, but the questions measuring long-term symptoms were found incompatible with the unidimensionality assumption of the model. The 8 core questions about symptom frequency and intensity were found to measure one latent variable, measurement precision was acceptable, and the model fit was reasonable. The response category structure functioned well. The CLDEQ-8 also functioned as one latent variable with acceptable measurement properties. The two scales were highly correlated in contact lens wearers (r = 0.73, p<0.001).
Conclusions: Overall, a short form of the SPEED questionnaire had good measurement properties in this large, diverse sample of adults. Both the SPEED and the CLDEQ-8 questionnaires seem to be tapping into a similar construct for dry eye symptoms.
Lisa A. Jones-Jordan Andrew D. Pucker, Justin Kwan
Race, Ethnicity, and Lifestyle Choice Associations with Meibomian Gland Atrophy Conference
2016, ISBN: E-abstract 160024.
@conference{Pucker2016,
title = {Race, Ethnicity, and Lifestyle Choice Associations with Meibomian Gland Atrophy},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Justin Kwan, Carolina M. Kunnen, Shruthi Srinivasan},
url = {https://www.aaopt.org/detail/knowledge-base-article/race-ethnicity-and-lifestyle-choice-associations-meibomian-gland-atrophy},
isbn = {E-abstract 160024},
year = {2016},
date = {2016-11-09},
abstract = {Purpose: The purpose of this study was to determine how race, ethnicity, and lifestyle choices were associated with meibomian gland atrophy (MGA) in a diverse convenience sample of optometry conference attendees.
Methods: This was a cross-sectional study open to all participants who attended the American Academy of Optometry’s 2015 annual meeting in New Orleans, LA. Subjects self-administered a study-specific survey that queried demographics, ocular history, symptoms, and lifestyle. MGA was assessed photographically with an infrared camera (OCULUS Keratograph 5M) by imaging the upper and lower eyelids. All images were then subjectively evaluated with Arita et al.’s 0 to 3 grading scale per eyelid by two masked examiners. Associations between the above variables and MGA of combined eyelids, upper eyelids, and lower eyelids were analyzed after taking the mean of the two examiners’ scores.
Results: A diverse group (67.6% white, 2.5% black, 25.0% Asian, 4.9% other) of contact lens (CL) (n = 151) and non-CL (n = 134) wearers were recruited. The population was 61.4% female. Significant combined eyelid MGA (upper plus lower eyelid scores >2 out of 6) was associated with age (P=0.006), female gender (P=0.03), and self-reported MG dysfunction (P=0.04). Significant combined atrophy was not associated with years of CL use (P=0.78), hours of exercise (P=0.64), time outdoors (P=0.19), race (P=1.0), ethnicity (P=0.45), or use of omega-3 fatty acid supplements (P=0.60). When eyelids were analyzed individually, significant upper eyelid MGA (scores >1 out of 3) was only associated with age (P=0.001) while significant lower eyelid MGA was only associated with time outdoors (P=0.05) and female gender (P=0.05).
Conclusions: This study primarily found an association between MGA and age; however, associations between MGA and factors depended upon which eyelids were analyzed indicating that a subanalysis by eyelid may be important for understanding MGA.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Purpose: The purpose of this study was to determine how race, ethnicity, and lifestyle choices were associated with meibomian gland atrophy (MGA) in a diverse convenience sample of optometry conference attendees.
Methods: This was a cross-sectional study open to all participants who attended the American Academy of Optometry’s 2015 annual meeting in New Orleans, LA. Subjects self-administered a study-specific survey that queried demographics, ocular history, symptoms, and lifestyle. MGA was assessed photographically with an infrared camera (OCULUS Keratograph 5M) by imaging the upper and lower eyelids. All images were then subjectively evaluated with Arita et al.’s 0 to 3 grading scale per eyelid by two masked examiners. Associations between the above variables and MGA of combined eyelids, upper eyelids, and lower eyelids were analyzed after taking the mean of the two examiners’ scores.
Results: A diverse group (67.6% white, 2.5% black, 25.0% Asian, 4.9% other) of contact lens (CL) (n = 151) and non-CL (n = 134) wearers were recruited. The population was 61.4% female. Significant combined eyelid MGA (upper plus lower eyelid scores >2 out of 6) was associated with age (P=0.006), female gender (P=0.03), and self-reported MG dysfunction (P=0.04). Significant combined atrophy was not associated with years of CL use (P=0.78), hours of exercise (P=0.64), time outdoors (P=0.19), race (P=1.0), ethnicity (P=0.45), or use of omega-3 fatty acid supplements (P=0.60). When eyelids were analyzed individually, significant upper eyelid MGA (scores >1 out of 3) was only associated with age (P=0.001) while significant lower eyelid MGA was only associated with time outdoors (P=0.05) and female gender (P=0.05).
Conclusions: This study primarily found an association between MGA and age; however, associations between MGA and factors depended upon which eyelids were analyzed indicating that a subanalysis by eyelid may be important for understanding MGA.
Methods: This was a cross-sectional study open to all participants who attended the American Academy of Optometry’s 2015 annual meeting in New Orleans, LA. Subjects self-administered a study-specific survey that queried demographics, ocular history, symptoms, and lifestyle. MGA was assessed photographically with an infrared camera (OCULUS Keratograph 5M) by imaging the upper and lower eyelids. All images were then subjectively evaluated with Arita et al.’s 0 to 3 grading scale per eyelid by two masked examiners. Associations between the above variables and MGA of combined eyelids, upper eyelids, and lower eyelids were analyzed after taking the mean of the two examiners’ scores.
Results: A diverse group (67.6% white, 2.5% black, 25.0% Asian, 4.9% other) of contact lens (CL) (n = 151) and non-CL (n = 134) wearers were recruited. The population was 61.4% female. Significant combined eyelid MGA (upper plus lower eyelid scores >2 out of 6) was associated with age (P=0.006), female gender (P=0.03), and self-reported MG dysfunction (P=0.04). Significant combined atrophy was not associated with years of CL use (P=0.78), hours of exercise (P=0.64), time outdoors (P=0.19), race (P=1.0), ethnicity (P=0.45), or use of omega-3 fatty acid supplements (P=0.60). When eyelids were analyzed individually, significant upper eyelid MGA (scores >1 out of 3) was only associated with age (P=0.001) while significant lower eyelid MGA was only associated with time outdoors (P=0.05) and female gender (P=0.05).
Conclusions: This study primarily found an association between MGA and age; however, associations between MGA and factors depended upon which eyelids were analyzed indicating that a subanalysis by eyelid may be important for understanding MGA.
Lisa A. Jones-Jordan Andrew D. Pucker, Shruthi Srinivasan
Is Compliance and Ocular Surface Factors Associated with Contact Lens Dropout? Conference
2016, ISBN: E-abstract 3933.
@conference{Pucker2016b,
title = {Is Compliance and Ocular Surface Factors Associated with Contact Lens Dropout? },
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Shruthi Srinivasan, Daniel R. Powell, Justin Kwan, Sebastian Marx, Wolfgang Sickenberger, Lyndon Jones},
isbn = {E-abstract 3933},
year = {2016},
date = {2016-11-09},
abstract = { },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Lisa A. Jones-Jordan Carolina M. Kunnen, Justin Kwan
2016.
@conference{Kunnen2016,
title = {The Association Between Meibomian Gland Width, Clinical Tests, and Patient-Reported Outcomes in Contact Lens and Non-Contact Lens Wearers},
author = {Carolina M. Kunnen, Lisa A. Jones-Jordan, Justin Kwan, Sruthi Srinivasan, Andrew D. Pucker},
url = {https://blog.jenvis-research.com/wp-content/uploads/2019/01/The-Association-Between-Meibomian-Gland-Width-Clinical-Tests-and-Patient-Reported-Outcomes-in-Contact-Lens-and-Non-Contact-Lens-Wearers-1.png},
year = {2016},
date = {2016-09-07},
abstract = { },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2015
Lisa A. Jones-Jordan Andrew D. Pucker, Wing Li
Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers Journal Article
In: 2015.
@article{Pucker2015b,
title = {Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Wing Li, Justin Kwan, Meng Ching Lin, Wolfgang Sickenberger, Sebastian Marx, Shruthi Srinivasan, Lyndon Jones},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26154690},
year = {2015},
date = {2015-09-01},
abstract = {PURPOSE:
To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study.
METHODS:
Contact lens wearers (case) and age- and sex-matched non-contact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms.
RESULTS:
A total of 70 matched pairs were analyzed. The mean (± SD) age of the CL group was 30.6 (± 12.4) years, and that of the NCL group was 30.1 (± 12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).
CONCLUSIONS:
This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE:
To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study.
METHODS:
Contact lens wearers (case) and age- and sex-matched non-contact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms.
RESULTS:
A total of 70 matched pairs were analyzed. The mean (± SD) age of the CL group was 30.6 (± 12.4) years, and that of the NCL group was 30.1 (± 12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).
CONCLUSIONS:
This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers.
To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study.
METHODS:
Contact lens wearers (case) and age- and sex-matched non-contact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms.
RESULTS:
A total of 70 matched pairs were analyzed. The mean (± SD) age of the CL group was 30.6 (± 12.4) years, and that of the NCL group was 30.1 (± 12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).
CONCLUSIONS:
This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers.
Andrew D. Pucker Lisa A. Jones-Jordan, Sruthi Srinavason
A Comparison of Meibomian Gland Expressibility Methods in Contact Lens and Non-Contact-Lens Wearers Conference
2015.
@conference{Jones-Jordan2015,
title = {A Comparison of Meibomian Gland Expressibility Methods in Contact Lens and Non-Contact-Lens Wearers},
author = {Lisa A. Jones-Jordan, Andrew D. Pucker, Sruthi Srinavason, Wing Li, Justin Kwan, Meng Ching Lin, Wolfgang Sickenberger, Lyndon W. Jones},
year = {2015},
date = {2015-05-20},
abstract = {Purpose: To compare two common meibum expressibility evaluation methods in a matched-pair sample of contact lens wearers (CLW) and non-contact lens wearers (NCLW).
Method: This was an age and gender matched case-control study to assess group differences in meibomian gland (MG) dysfunction. Meibum expressibility was assessed with two methods, A:
with a mechanical device specifically designed for MG expression (Meibomian Gland Evaluator, TearScience) and B: with the traditional finger expression method. Both methods were sequentially performed on the lower eyelids of each subject. Meibum expressibility and quality were graded with established scales. Means±SD were given for continuous variables and frequencies for categorical data. McNemar’s tests were done by group to compare the agreement between the two methods and weighted kappas were reported.
Results: Data from 138 subjects (mean age = 30.7±12.2yrs; F: 70%; M:30%) were used. About 75% of subjects had no or mild plugged glands when using method B, while about 60% had no or mild plugged glands with method A. Weighted kappas (WK) comparing agreement for two expressibility methods were similar between eyes (right eye is reported). The WK for NCLW was 0.76 (95% confidence interval (CI): 0.66–0.86), and for CLW was 0.77 (95% CI: 0.67–0.86). The kappas were not different between groups (p = 0.89). Right eye WKs for meibum quality were similar between the groups (p = 0.55).
Conclusions: The agreement between the two meibum expressibility evaluation methods showed similar results, indicating that either method could be used. The agreement between the weighted kappas for CLW and NCLW indicated no reason to vary measurement methods dependent on CLW status.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Purpose: To compare two common meibum expressibility evaluation methods in a matched-pair sample of contact lens wearers (CLW) and non-contact lens wearers (NCLW).
Method: This was an age and gender matched case-control study to assess group differences in meibomian gland (MG) dysfunction. Meibum expressibility was assessed with two methods, A:
with a mechanical device specifically designed for MG expression (Meibomian Gland Evaluator, TearScience) and B: with the traditional finger expression method. Both methods were sequentially performed on the lower eyelids of each subject. Meibum expressibility and quality were graded with established scales. Means±SD were given for continuous variables and frequencies for categorical data. McNemar’s tests were done by group to compare the agreement between the two methods and weighted kappas were reported.
Results: Data from 138 subjects (mean age = 30.7±12.2yrs; F: 70%; M:30%) were used. About 75% of subjects had no or mild plugged glands when using method B, while about 60% had no or mild plugged glands with method A. Weighted kappas (WK) comparing agreement for two expressibility methods were similar between eyes (right eye is reported). The WK for NCLW was 0.76 (95% confidence interval (CI): 0.66–0.86), and for CLW was 0.77 (95% CI: 0.67–0.86). The kappas were not different between groups (p = 0.89). Right eye WKs for meibum quality were similar between the groups (p = 0.55).
Conclusions: The agreement between the two meibum expressibility evaluation methods showed similar results, indicating that either method could be used. The agreement between the weighted kappas for CLW and NCLW indicated no reason to vary measurement methods dependent on CLW status.
Method: This was an age and gender matched case-control study to assess group differences in meibomian gland (MG) dysfunction. Meibum expressibility was assessed with two methods, A:
with a mechanical device specifically designed for MG expression (Meibomian Gland Evaluator, TearScience) and B: with the traditional finger expression method. Both methods were sequentially performed on the lower eyelids of each subject. Meibum expressibility and quality were graded with established scales. Means±SD were given for continuous variables and frequencies for categorical data. McNemar’s tests were done by group to compare the agreement between the two methods and weighted kappas were reported.
Results: Data from 138 subjects (mean age = 30.7±12.2yrs; F: 70%; M:30%) were used. About 75% of subjects had no or mild plugged glands when using method B, while about 60% had no or mild plugged glands with method A. Weighted kappas (WK) comparing agreement for two expressibility methods were similar between eyes (right eye is reported). The WK for NCLW was 0.76 (95% confidence interval (CI): 0.66–0.86), and for CLW was 0.77 (95% CI: 0.67–0.86). The kappas were not different between groups (p = 0.89). Right eye WKs for meibum quality were similar between the groups (p = 0.55).
Conclusions: The agreement between the two meibum expressibility evaluation methods showed similar results, indicating that either method could be used. The agreement between the weighted kappas for CLW and NCLW indicated no reason to vary measurement methods dependent on CLW status.
Lisa A. Jones-Jordan Andrew D. Pucker, Justin Kwan
A Comparison of SPEED Scores in Contact Lens and Non-Contact Lens Wearers Conference
2015.
@conference{Pucker2015,
title = {A Comparison of SPEED Scores in Contact Lens and Non-Contact Lens Wearers},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Justin Kwan, Carolina M. Kunnen, Shruthi Srinivasan},
year = {2015},
date = {2015-05-01},
abstract = {Purpose: The purpose of this analysis was to determine if the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire is able to similarly detect dry eye in both contact lens (CL) and non-contact lens wearers (NCL).
Methods: This was a cross-sectional study open to all participants who attended the American Academy of Optometry’s 2015 annual meeting in New Orleans, LA. All subjects were administered a study-specific demographics survey that also asked about self-reported dry eye status and the SPEED questionnaire. Tear meniscus height (TMH) was photographically assessed (OCULUS keratograph 5M) and tear volume (Zone-QuickTM Phenol Red Thread) was evaluated. Subjects were then classified as having dry eye if they had two or more positive dry eye tests (self-reported dry eye, TMH, tear volume). SPEED scores in CL and NCL wearers were then compared to dry eye status to determine the SPEED questionnaire’s ability to detect dry eye.
Results: A diverse group (67.6% white, 2.5% black, 25.0% Asian, 4.9% other) of CL (n = 150) and NCL (n = 134) wearers were recruited. The mean ± SD age of the CL and NCL wearers was 34.5 ± 12.6 years and 40.6 ± 15.1 years, respectively. The population was predominantly female (61.4% female), and a large portion of the CL (58.3%) and NCL (41.8%) self-reported dry eye. The mean SPEED scores (CL = 7.5 ± 4.7; NCL = 7.3 ± 5.0) and tear volumes (CL = 4.34 ± 5.08 mm; NCL = 3.93 ± 3.80 mm) were not significantly different between groups (p > 0.05), yet TMHs (CL = 0.22 ± 0.11 mm, NCL = 0.27 ± 0.12 mm) were significantly lower in the CL group (p = 0.0004). The SPEED scores were found to be associated with dry eye status in NCL wearers (r = 0.35, p <0.001) but not CL wearers (r = 0.12, p = 0.13).
Conclusions: Meeting attendees easily completed the SPEED questionnaire. While the SPEED questionnaire was able to predict the dry eye status of NCL wearers, it was unable to predict the dry eye status of a CL wearer in this sample. Additional work should be done to assess the usefulness of the SPEED questionnaire in CL-wearing populations.
},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Purpose: The purpose of this analysis was to determine if the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire is able to similarly detect dry eye in both contact lens (CL) and non-contact lens wearers (NCL).
Methods: This was a cross-sectional study open to all participants who attended the American Academy of Optometry’s 2015 annual meeting in New Orleans, LA. All subjects were administered a study-specific demographics survey that also asked about self-reported dry eye status and the SPEED questionnaire. Tear meniscus height (TMH) was photographically assessed (OCULUS keratograph 5M) and tear volume (Zone-QuickTM Phenol Red Thread) was evaluated. Subjects were then classified as having dry eye if they had two or more positive dry eye tests (self-reported dry eye, TMH, tear volume). SPEED scores in CL and NCL wearers were then compared to dry eye status to determine the SPEED questionnaire’s ability to detect dry eye.
Results: A diverse group (67.6% white, 2.5% black, 25.0% Asian, 4.9% other) of CL (n = 150) and NCL (n = 134) wearers were recruited. The mean ± SD age of the CL and NCL wearers was 34.5 ± 12.6 years and 40.6 ± 15.1 years, respectively. The population was predominantly female (61.4% female), and a large portion of the CL (58.3%) and NCL (41.8%) self-reported dry eye. The mean SPEED scores (CL = 7.5 ± 4.7; NCL = 7.3 ± 5.0) and tear volumes (CL = 4.34 ± 5.08 mm; NCL = 3.93 ± 3.80 mm) were not significantly different between groups (p > 0.05), yet TMHs (CL = 0.22 ± 0.11 mm, NCL = 0.27 ± 0.12 mm) were significantly lower in the CL group (p = 0.0004). The SPEED scores were found to be associated with dry eye status in NCL wearers (r = 0.35, p <0.001) but not CL wearers (r = 0.12, p = 0.13).
Conclusions: Meeting attendees easily completed the SPEED questionnaire. While the SPEED questionnaire was able to predict the dry eye status of NCL wearers, it was unable to predict the dry eye status of a CL wearer in this sample. Additional work should be done to assess the usefulness of the SPEED questionnaire in CL-wearing populations.
Methods: This was a cross-sectional study open to all participants who attended the American Academy of Optometry’s 2015 annual meeting in New Orleans, LA. All subjects were administered a study-specific demographics survey that also asked about self-reported dry eye status and the SPEED questionnaire. Tear meniscus height (TMH) was photographically assessed (OCULUS keratograph 5M) and tear volume (Zone-QuickTM Phenol Red Thread) was evaluated. Subjects were then classified as having dry eye if they had two or more positive dry eye tests (self-reported dry eye, TMH, tear volume). SPEED scores in CL and NCL wearers were then compared to dry eye status to determine the SPEED questionnaire’s ability to detect dry eye.
Results: A diverse group (67.6% white, 2.5% black, 25.0% Asian, 4.9% other) of CL (n = 150) and NCL (n = 134) wearers were recruited. The mean ± SD age of the CL and NCL wearers was 34.5 ± 12.6 years and 40.6 ± 15.1 years, respectively. The population was predominantly female (61.4% female), and a large portion of the CL (58.3%) and NCL (41.8%) self-reported dry eye. The mean SPEED scores (CL = 7.5 ± 4.7; NCL = 7.3 ± 5.0) and tear volumes (CL = 4.34 ± 5.08 mm; NCL = 3.93 ± 3.80 mm) were not significantly different between groups (p > 0.05), yet TMHs (CL = 0.22 ± 0.11 mm, NCL = 0.27 ± 0.12 mm) were significantly lower in the CL group (p = 0.0004). The SPEED scores were found to be associated with dry eye status in NCL wearers (r = 0.35, p <0.001) but not CL wearers (r = 0.12, p = 0.13).
Conclusions: Meeting attendees easily completed the SPEED questionnaire. While the SPEED questionnaire was able to predict the dry eye status of NCL wearers, it was unable to predict the dry eye status of a CL wearer in this sample. Additional work should be done to assess the usefulness of the SPEED questionnaire in CL-wearing populations.
2014
Lisa A. Jones-Jordan Andrew D. Pucker, Wing Li
Factors Associated with Meibomian Gland Atrophy in Daily Contact Lens Wearers Conference
2014.
@conference{Pucker2014,
title = {Factors Associated with Meibomian Gland Atrophy in Daily Contact Lens Wearers},
author = {Andrew D. Pucker, Lisa A. Jones-Jordan, Wing Li, Justin Kwan, Meng Lin, Wolfgang Sickenberger, Sebastian Marx, Sruthi Srinivasan, Lyndon Jones},
url = {https://blog.jenvis-research.com/wp-content/uploads/2019/01/Factors-Associated-with-Meibomian-Gland-Atrophy-in-Daily-Contact-Lens-Wearers.pdf},
year = {2014},
date = {2014-11-14},
abstract = {Purpose: To determine factors associated with contact lens related meibomian gland atrophy in a matched pair sample.
Methods: Contact lens wearers (case) and age- and gender-matched non-contact lens wearers with no significant history of contact lens use (control) were recruited across five study sites in three countries. All subjects were administered an Ocular Surface Disease Index (OSDI) questionnaire, and tear meniscus height, non-invasive tear break-up time, tear osmolarity, lid wiper epitheliopathy, lid parallel conjunctival folds, line of Marx, conjunctival staining, upper eyelid meibomian gland expressibility, Schirmer’s test, and meibomian gland atrophy were assessed. Univariate conditional logistic regression was then used to determine relationships between meibomian gland atrophy and clinical signs and symptoms.
Results: Subjects included 118 adults (59 matched pairs). Mean ± SD age was 28.4 ± 9.9 years; 69% of the subjects were female. No significant associations were found between meibomian gland atrophy and the following variables: OSDI (P = 0.55), tear meniscus height (P = 0.85), non-invasive tear break-up time (P = 0.58), tear osmolarity (P = 0.56), lid wiper epitheliopathy (P = 0.34), lid parallel conjunctival folds (P = 0.42), line of Marx (P = 0.32), conjunctival staining (P = 0.36), Schirmer’s test (P = 0.05), and meibomian gland expressibility (P = 0.81). Unpaired analysis comparing subject age and meibomian gland atrophy also found no association.
Conclusions: These data indicate that there are no significant differences between contact lens wearers and non-contact lens wearers in this cohort of relatively young lens wearers, when comparing meibomian gland atrophy to clinical dry eye signs and symptoms. No association between meibomian gland atrophy and age was found, which is in contrast to past studies.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Purpose: To determine factors associated with contact lens related meibomian gland atrophy in a matched pair sample.
Methods: Contact lens wearers (case) and age- and gender-matched non-contact lens wearers with no significant history of contact lens use (control) were recruited across five study sites in three countries. All subjects were administered an Ocular Surface Disease Index (OSDI) questionnaire, and tear meniscus height, non-invasive tear break-up time, tear osmolarity, lid wiper epitheliopathy, lid parallel conjunctival folds, line of Marx, conjunctival staining, upper eyelid meibomian gland expressibility, Schirmer’s test, and meibomian gland atrophy were assessed. Univariate conditional logistic regression was then used to determine relationships between meibomian gland atrophy and clinical signs and symptoms.
Results: Subjects included 118 adults (59 matched pairs). Mean ± SD age was 28.4 ± 9.9 years; 69% of the subjects were female. No significant associations were found between meibomian gland atrophy and the following variables: OSDI (P = 0.55), tear meniscus height (P = 0.85), non-invasive tear break-up time (P = 0.58), tear osmolarity (P = 0.56), lid wiper epitheliopathy (P = 0.34), lid parallel conjunctival folds (P = 0.42), line of Marx (P = 0.32), conjunctival staining (P = 0.36), Schirmer’s test (P = 0.05), and meibomian gland expressibility (P = 0.81). Unpaired analysis comparing subject age and meibomian gland atrophy also found no association.
Conclusions: These data indicate that there are no significant differences between contact lens wearers and non-contact lens wearers in this cohort of relatively young lens wearers, when comparing meibomian gland atrophy to clinical dry eye signs and symptoms. No association between meibomian gland atrophy and age was found, which is in contrast to past studies.
Methods: Contact lens wearers (case) and age- and gender-matched non-contact lens wearers with no significant history of contact lens use (control) were recruited across five study sites in three countries. All subjects were administered an Ocular Surface Disease Index (OSDI) questionnaire, and tear meniscus height, non-invasive tear break-up time, tear osmolarity, lid wiper epitheliopathy, lid parallel conjunctival folds, line of Marx, conjunctival staining, upper eyelid meibomian gland expressibility, Schirmer’s test, and meibomian gland atrophy were assessed. Univariate conditional logistic regression was then used to determine relationships between meibomian gland atrophy and clinical signs and symptoms.
Results: Subjects included 118 adults (59 matched pairs). Mean ± SD age was 28.4 ± 9.9 years; 69% of the subjects were female. No significant associations were found between meibomian gland atrophy and the following variables: OSDI (P = 0.55), tear meniscus height (P = 0.85), non-invasive tear break-up time (P = 0.58), tear osmolarity (P = 0.56), lid wiper epitheliopathy (P = 0.34), lid parallel conjunctival folds (P = 0.42), line of Marx (P = 0.32), conjunctival staining (P = 0.36), Schirmer’s test (P = 0.05), and meibomian gland expressibility (P = 0.81). Unpaired analysis comparing subject age and meibomian gland atrophy also found no association.
Conclusions: These data indicate that there are no significant differences between contact lens wearers and non-contact lens wearers in this cohort of relatively young lens wearers, when comparing meibomian gland atrophy to clinical dry eye signs and symptoms. No association between meibomian gland atrophy and age was found, which is in contrast to past studies.
Andrew D. Pucker Sruthi Srinivasan, Lisa A. Jones-Jordan
Meibomian Gland Atrophy Rate in Pre-presbyopic Contact Lens and Non-Contact Lens Wearers Conference
2014.
@conference{Srinivasan2014,
title = {Meibomian Gland Atrophy Rate in Pre-presbyopic Contact Lens and Non-Contact Lens Wearers},
author = {Sruthi Srinivasan, Andrew D. Pucker, Lisa A. Jones-Jordan, Wing Li, Justin Kwan, Wolfgang Sickenberger, Sebastian Marx, Meng Chin Lin, Lyndon W. Jones},
url = {https://blog.jenvis-research.com/wp-content/uploads/2019/01/Meibomian-Gland-Atrophy-Rate-in-Pre-presbyopic-Contact-Lens-and-Non-Contact-Lens-Wearers-1.pdf},
year = {2014},
date = {2014-11-12},
abstract = {Purpose: To determine the rate of meibomian gland (MG) atrophy in a matched-pair sample of contact lens (CL) and non-contact-lens (NCL) wearers. Methods: CL wearers with a minimum of five years of CL use and NCL wearers who were age- and gender-matched were recruited across five study sites from three countries (USA, Canada and Germany). Lower and upper eyelids of all participants were everted and MGs were imaged using the Keratograph 5M infrared camera (OCULUS). MG atrophy (percent) was determined by analyzing the mean gland loss of the upper and lower eyelids in the most affected eye. Digital analyses of the images were conducted using ImageJ software. General linear regression models were used to determine MG atrophy rates in CL and NCL wearers to account for the matched design. Results:A total of 118 participants were included in the analysis. Mean ± SD age was 28.4 ± 9.9 yrs; 41F and 18M pairs were collected. Mean MG atrophy in the CL group was 25.8% and 24.0% in the NCL group (p=0.41). Neither age (p=0.39) nor gender (p=0.43) was significantly associated with MG atrophy in this cohort. No significant differences were found for different age groups (<20, 20-24, 25-29, 30+ years; p= 0.40). There was a 0.19 % increase per year in MG atrophy in CL wearers compared with a 0.003% increase per year in NCL wearers. Number of years of CL wear was also not significantly associated with MG atrophy (p=0.50). Conclusions: MG atrophy rates in CL and NCL wearers were similar in this cohort of pre-presbyopic participants. It was also noted that age, gender and years of CL wear were not associated with MG atrophy.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Purpose: To determine the rate of meibomian gland (MG) atrophy in a matched-pair sample of contact lens (CL) and non-contact-lens (NCL) wearers. Methods: CL wearers with a minimum of five years of CL use and NCL wearers who were age- and gender-matched were recruited across five study sites from three countries (USA, Canada and Germany). Lower and upper eyelids of all participants were everted and MGs were imaged using the Keratograph 5M infrared camera (OCULUS). MG atrophy (percent) was determined by analyzing the mean gland loss of the upper and lower eyelids in the most affected eye. Digital analyses of the images were conducted using ImageJ software. General linear regression models were used to determine MG atrophy rates in CL and NCL wearers to account for the matched design. Results:A total of 118 participants were included in the analysis. Mean ± SD age was 28.4 ± 9.9 yrs; 41F and 18M pairs were collected. Mean MG atrophy in the CL group was 25.8% and 24.0% in the NCL group (p=0.41). Neither age (p=0.39) nor gender (p=0.43) was significantly associated with MG atrophy in this cohort. No significant differences were found for different age groups (<20, 20-24, 25-29, 30+ years; p= 0.40). There was a 0.19 % increase per year in MG atrophy in CL wearers compared with a 0.003% increase per year in NCL wearers. Number of years of CL wear was also not significantly associated with MG atrophy (p=0.50). Conclusions: MG atrophy rates in CL and NCL wearers were similar in this cohort of pre-presbyopic participants. It was also noted that age, gender and years of CL wear were not associated with MG atrophy.